Octreotide (Injection Route, Intramuscular Route, Subcutaneous Route)

Name: Octreotide (Injection Route, Intramuscular Route, Subcutaneous Route)

US Brand Name

  1. SandoSTATIN
  2. SandoSTATIN LAR Depot

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of the short-acting form of octreotide injection in the pediatric population. Safety and efficacy have not been demonstrated.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of the long-acting form of octreotide injection in children 6 to 17 years of age. Safety and efficacy have not been established in children younger than 6 years of age.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Cholangitis (inflammation or swelling of the bile duct) or
  • Congestive heart failure or
  • Gallbladder disease or
  • Gallstones, or history of or
  • Heart rhythm problems (eg, arrhythmia, QT prolongation, slow heartbeat) or
  • Pancreatitis (inflammation or swelling of the pancreas) or
  • Thyroid problems or
  • Vitamin B12 deficiency—Use with caution. May make these conditions worse.
  • Diabetes—Octreotide may cause high or low blood sugar. Your doctor may need to change the dose of your insulin or diabetes medicine.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For long-acting injection dosage form:
    • For treatment of acromegaly:
      • Adults—At first, 20 milligrams (mg) injected into the buttocks once every 4 weeks for 3 months. Your doctor will adjust your dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.
    • For treatment of severe diarrhea and other symptoms that occur with certain types of intestinal tumors:
      • Adults—At first, 20 milligrams (mg) injected into the muscles once every 4 weeks for 2 months. Your doctor will adjust your dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.
  • For short-acting injection dosage form (solution):
    • For treatment of acromegaly:
      • Adults—At first, 50 micrograms (mcg) given as a shot under the skin 3 times a day. Your doctor will adjust your dose as needed.
      • Children—Use and dose must be determined by your doctor.
    • For treatment of carcinoid tumors:
      • Adults—At first, 100 to 600 micrograms (mcg) per day, given in 2 to 4 divided doses, injected under the skin for the first 2 weeks. Your doctor will adjust your dose as needed. However, the dose is usually not more than 1500 mcg per day.
      • Children—Use and dose must be determined by your doctor.
    • For treatment of severe diarrhea that occurs with certain types of intestinal tumors:
      • Adults—At first, 200 to 300 micrograms (mcg) per day, given in 2 to 4 divided doses, injected under the skin for the first 2 weeks. Your doctor will adjust your dose as needed. However, the dose is usually not more than 450 mcg per day.
      • Children—Use and dose must be determined by your doctor.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also keep the vials at room temperature, away from heat and direct light, for up to 14 days. Throw away any unused medicine after 14 days.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

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