- Icatibant icatibant injection
- Icatibant names
- Icatibant action
- Icatibant dosage
- Icatibant 30 mg
- Icatibant injection
- Icatibant side effects
- Icatibant and side effects
- Icatibant drug
- Icatibant side effects of icatibant
- Icatibant effects of icatibant
What is the most important information I should know about icatibant?
You should not use icatibant if you are allergic to it.
To make sure you can safely use icatibant, tell your doctor about all of your medical conditions, if you use heart or blood pressure medications, and if you are pregnant or breast-feeding.
Get emergency medical help if you have any swelling of your tongue or throat during an angioedema attack.
An allergic reaction to icatibant can cause symptoms that are very similar to the signs of hereditary angioedema, including: hives, trouble breathing, or swelling of your face, lips, tongue, or throat.
Do not use more than 3 icatibant injections within a 24-hour period. Call your doctor if your symptoms do not improve, or if they get worse after using this medication.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include redness, itching, or feeling like you might pass out.
Brand Names U.S.
Onset of Action
Median time to 50% decrease of symptoms: ~2 hours
Time to Peak
Special Populations Elderly
Elderly subjects had a 2-fold higher AUC compared with younger subjects. Only minor differences (12% to 14%) in Cmax were observed. No dosage adjustment is needed.
Use Labeled Indications
Hereditary angioedema: Treatment of acute attacks of hereditary angioedema (HAE)
Hereditary angioedema (HAE): SubQ: 30 mg; may repeat every 6 hours if response is inadequate or symptoms recur (maximum daily dose: 90 mg).
ACE inhibitor-induced angioedema (off-label use): SubQ: 30 mg; if symptoms of angioedema continue to worsen after 6 hours, a second injection may be administered. The authors administered intravenous prednisolone (not available in the US) with the second dose of icatibant (Bas, 2015).
Refer to adult dosing. Systemic exposure may be increased; however, no dosage adjustments are recommended.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience dizziness, nausea, or headache. Have patient report immediately to prescriber severe injection site irritation (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.
For the Consumer
Applies to icatibant: subcutaneous solution
Along with its needed effects, icatibant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking icatibant:Less common
Some side effects of icatibant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site