Etanercept-Ykro (Subcutaneous Route)

Name: Etanercept-Ykro (Subcutaneous Route)

US Brand Name

  1. Eticovo

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of etanercept-ykro injection in children with juvenile idiopathic arthritis younger than 2 years of age and in children with psoriasis younger than 4 years of age. Safety and efficacy have not been established in these age groups.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcoholic hepatitis, moderate to severe or
  • Blood or bone marrow problems (eg, aplastic anemia, low white blood cells), history of or
  • Congestive heart failure, history of or
  • Nervous system problems (eg, Guillain-Barré syndrome, multiple sclerosis, demyelinating disease) or
  • Optic neuritis (inflammation of the eye nerve) or
  • Psoriasis (skin disease) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Cancer, history of or
  • Diabetes or
  • Disease of the immune system, history of or
  • Infections (eg, hepatitis B, bacteria, fungus, virus), active or history of or
  • Tuberculosis, active or history of or
  • Wegener’s granulomatosis (inflammation of the blood vessels that affects the lungs, kidneys, or other organs)—Patients with these conditions may have an increased chance for side effects.
  • Sepsis (serious infection in the blood)—Should not be used in patients with this condition.
  • Varicella zoster (chickenpox) infection—Should be treated first before using this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage forms (solution):
    • For juvenile idiopathic arthritis:
      • Children 2 years of age and older weighing 63 kilograms (kg) or more—50 milligrams (mg) injected under the skin once a week.
      • Children 2 years of age and older weighing less than 63 kg—Dose is based on body weight and must be determined by your doctor.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For plaque psoriasis:
      • Adults—At first, 50 milligrams (mg) injected under the skin 2 times per week, given 3 or 4 days apart, for 3 months. Then, your dose will be reduced to 50 mg once a week.
      • Children 4 years of age and older weighing 63 kilograms (kg) or more—50 milligrams (mg) injected under the skin once a week.
      • Children 4 years of age and older weighing less than 63 kg—Dose is based on body weight and must be determined by your doctor.
      • Children younger than 4 years of age—Use and dose must be determined by your doctor.
    • For rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis:
      • Adults—50 milligrams (mg) injected under the skin once a week.
      • Children—Use and dose must be determined by your doctor.
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