Estrace (Estradiol Vaginal Cream)

Name: Estrace (Estradiol Vaginal Cream)

Uses of Estrace

  • It is used to treat vaginal irritation and dryness caused by change of life.
  • It may be given to you for other reasons. Talk with the doctor.

What are some things I need to know or do while I take Estrace?

  • Tell all of your health care providers that you take Estrace. This includes your doctors, nurses, pharmacists, and dentists.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
  • High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine.
  • Do not smoke. Smoking raises the chance of heart disease. Talk with your doctor.
  • Limit your drinking of alcohol.
  • If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
  • This medicine may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
  • Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
  • If you are 65 or older, use Estrace with care. You could have more side effects.
  • This medicine is not approved for use in children. Talk with the doctor.

How do I store and/or throw out Estrace?

  • Store at room temperature.
  • Protect from heat.
  • Store in original container.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Estrace, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Estrace. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Estrace (estradiol vaginal cream).

Review Date: October 4, 2017

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; change in stools; dark urine or yellow skin or eyes; or fever with chills.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Chest pain or pressure.
  • Shortness of breath.
  • Coughing up blood.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Very bad headache.
  • Very bad dizziness or passing out.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Very upset stomach or throwing up.
  • Very bad belly pain.
  • Pelvic pain or pressure.
  • Very bad vaginal irritation.
  • Vaginal itching or discharge.
  • Vaginal bleeding that is not normal.
  • A lump in the breast, breast soreness, or nipple discharge.
  • Breast pain.
  • Low mood (depression).
  • Mood changes.
  • Memory problems or loss.
  • Bulging eyes.
  • Change in how contact lenses feel in the eyes.
  • Change in eyesight.
  • Loss of eyesight.
  • Swelling.

Estradiol topical Pregnancy Warnings

Animal studies have revealed that high doses of estrogens have produced urogenital malformations in the offspring. There are no adequate and well-controlled studies in pregnant women. AU TGA pregnancy category B 3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans. US FDA pregnancy category X: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Use is contraindicated during pregnancy. AU TGA pregnancy category: B 3 US FDA pregnancy category: X Comments: -If pregnancy occurs while this drug is being, treatment should be discontinued immediately. -There is little or no increased risk of birth defects in children born to women who have used estrogens and progestins inadvertently during early pregnancy.

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