Eltrombopag (Oral Route)

Name: Eltrombopag (Oral Route)

Descriptions

Eltrombopag is used to treat thrombocytopenia (low platelets in the blood) in adults and children 1 year of age and older with a blood disorder called chronic idiopathic thrombocytopenic purpura (ITP). This medicine is used after a splenectomy (surgery to remove the spleen) and other medicines, such as steroids or immunoglobulin, have not worked well enough. Eltrombopag is also used to treat thrombocytopenia in patients with chronic hepatitis C, along with interferon therapy. Platelets help clot the blood, so a person with thrombocytopenia may have bleeding problems. Eltrombopag works by stimulating the bone marrow to produce more platelets.

Eltrombopag is also used to treat severe aplastic anemia (SAA) in patients who have received other medicines to treat SAA, when those medications did not work well.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Powder for Suspension

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Grazoprevir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum
  • Calcium
  • Ciprofloxacin
  • Eluxadoline
  • Fluvoxamine
  • Gemfibrozil
  • Iron
  • Magnesium
  • Mexiletine
  • Pixantrone
  • Propafenone
  • Selenium
  • Simvastatin
  • Topotecan
  • Trimethoprim
  • Zileuton
  • Zinc

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atorvastatin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Fluvastatin
  • Levothyroxine
  • Lopinavir
  • Methotrexate
  • Nateglinide
  • Penicillin G
  • Pravastatin
  • Repaglinide
  • Rifampin
  • Rosuvastatin

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (suspension or tablets):
    • For severe aplastic anemia:
      • Adults—At first, 50 milligrams (mg) once a day. Some patients may start at a lower dose. Your doctor may adjust your dose if needed. However, the dose is usually not more than 150 mg per day.
      • Children—Use and dose must be determined by your doctor.
    • For thrombocytopenia with ITP:
      • Adults and children 6 years of age and older—At first, 50 milligrams (mg) once a day. Some patients may start at a lower dose. Your doctor may adjust your dose if needed. However, the dose is usually not more than 75 mg per day.
      • Children 1 to 5 years of age—At first, 25 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 75 mg per day.
      • Children younger than 1 year of age—Use and dose must be determined by your doctor.
    • For thrombocytopenia with chronic hepatitis C:
      • Adults—At first, 25 milligrams (mg) once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 100 mg per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

(web3)