Benzedrex

Name: Benzedrex

Introduction

Vasoconstrictor, an aliphatic amine.a

Cautions for Benzedrex

Warnings/Precautions

General Precautions

Overuse

Possible irritation of nasal mucosa and adverse systemic effects (particularly in children) with excessive dosage and/or prolonged or too frequent use.a Possible rebound congestion (rhinitis, chronic redness and swelling of the nasal mucosa); avoid prolonged use.a b (See Advice to Patients.)

Overdosage following oral ingestion may result in psychotic reactions, palpitation, ventricular extrasystoles, and shock.a

Sympathomimetic Effects

Possible headache, hypertension, nervousness, and increased ventricular rate.a Use with caution in patients with thyroid disease (e.g., hyperthyroidism), heart disease, hypertension, or diabetes mellitus.a

Specific Populations

Pregnancy

Safety during pregnancy not established.a

Pediatric Use

Safety and efficacy not established in children <6 years of age.a b

Possible irritation of nasal mucosa and adverse systemic effects associated with excessive dosage, prolonged or too frequent use, or inadvertent ingestion of nasal solution.a

Common Adverse Effects

Burning, stinging, sneezing, increase in nasal discharge. a b

Benzedrex Pharmacokinetics

Absorption

Bioavailability

Occasionally, absorption may be sufficient to produce systemic effects.a

Onset

Following intranasal administration, local vasoconstriction usually occurs within 0.5–5 minutes.a

Duration

Following intranasal administration, local vasoconstriction persists for 30–120 minutes.a

Elimination

Metabolism

Metabolized in the liver.a

Elimination Route

Excreted in urine as unchanged drug and metabolites.a

Stability

Storage

Intranasal

Inhaler

Tight container at 15–30°C.b Avoid excessive heat.a

Inhaler remains potent for 2–3 months after first use, depending on the degree of use.a b

Actions

  • Structurally and pharmacologically related to amphetamine.a

  • Exact mechanism of action unknown but thought to be similar to amphetamine.a

  • Indirectly stimulates α-adrenergic receptors of the sympathetic nervous system; exerts a minor stimulant effect on β-adrenergic receptors.a

  • Intranasal application constricts dilated arterioles, reduces nasal blood flow and congestion, and may open obstructed eustachian ostia.a Temporarily improves nasal ventilation and aeration.a

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Propylhexedrine

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Nasal

Inhalant

250 mg

Benzedrex Inhaler

Ascher

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