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Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using probenecid.
Many drugs can interact with probenecid. Below is just a partial list. Tell your doctor if you are using:
- lorazepam (Ativan);
- methotrexate (Rheumatrex, Trexall);
- rifampin (Rifadin, Rifamate, Rimactane);
- diabetes medication you take by mouth;
- an NSAID (nonsteroidal anti-inflammatory drug) such as ketoprofen (Orudis, Oruvail), indomethacin (Indocin), meclofenamate (Meclomen), or naproxen (Aleve, Anaprox, Naprosyn);
- salicylates such as aspirin, Novasal, Doan's Extra Strength, Salflex, Tricosal, and others; or
- a sulfa drug such as Bactrim, Cotrim, Septra, SMX/TMP, and others.
This list is not complete and there may be other drugs that can interact with probenecid. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
What should I discuss with my healthcare provider before taking Benemid (probenecid)?
You should not use this medication if you are allergic to probenecid, or if you have:
uric acid kidney stones;
a gout attack that has already started; or
a blood cell disorder such as anemia, or decreased white blood cells.
Before taking probenecid, tell your doctor if you are allergic to any drugs, or if you have:
a history of stomach ulcer; or
if you have ever had kidney stones.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take probenecid.
Probenecid may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether probenecid passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Probenecid should not be given to a child younger than 2 years old.
Benemid (probenecid) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
worsening gout symptoms;
severe pain in your side or lower back;
blood in your urine;
swelling, especially in your face, stomach, ankles, or feet; or
pale or yellowed skin, dark colored urine, fever, confusion or weakness.
Less serious side effects may include:
urinating more than usual;
mild nausea, vomiting, loss of appetite;
mild itching or skin rash;
hair loss; or
warmth, redness, or tingly feeling under your skin.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Uses For Benemid
Probenecid is used in the treatment of chronic gout or gouty arthritis. These conditions are caused by too much uric acid in the blood. The medicine works by removing the extra uric acid from the body. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. This medicine will help prevent gout attacks only as long as you continue to take it.
Probenecid is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body.
Probenecid is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections.
Probenecid is available only with your doctor's prescription.
Proper Use of probenecid
This section provides information on the proper use of a number of products that contain probenecid. It may not be specific to Benemid. Please read with care.
If probenecid upsets your stomach, it may be taken with food. If this does not work, an antacid may be taken. If stomach upset (nausea, vomiting, or loss of appetite) continues, check with your doctor.
For patients taking probenecid for gout:
- After you begin to take probenecid, gout attacks may continue to occur for a while. However, if you take this medicine regularly as directed by your doctor, the attacks will gradually become less frequent and less painful than before. After you have been taking probenecid for several months, they may stop completely.
- This medicine will help prevent gout attacks but it will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take this medicine also. If you have any questions about this, check with your doctor.
For patients taking probenecid for gout or to help remove uric acid from the body:
- When you first begin taking probenecid, the amount of uric acid in the kidneys is greatly increased. This may cause kidney stones or other kidney problems in some people. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. It is important that you follow your doctor's instructions very carefully.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For treating gout or removing uric acid from the body:
- Adults: 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks. After this, the dose will depend on the amount of uric acid in your blood or urine. Most people need 2, 3, or 4 tablets a day, but some people may need higher doses.
- Children: It is not likely that probenecid will be needed to treat gout or to remove uric acid from the body in children. If a child needs this medicine, however, the dose would have to be determined by the doctor.
- For helping antibiotics work better:
- Adults: The amount of probenecid will depend on the condition being treated. Sometimes, only one dose of 2 tablets is needed. Other times, the dose will be 1 tablet four times a day.
- Children: The dose will have to be determined by the doctor. It depends on the child's weight, as well as on the condition being treated. Older children and teenagers may need the same amount as adults.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using Benemid
If you will be taking probenecid for more than a few weeks, your doctor should check your progress at regular visits.
Before you have any medical tests, tell the person in charge that you are taking this medicine. The results of some tests may be affected by probenecid.
For diabetic patients:
- Probenecid may cause false test results with copper sulfate urine sugar tests (Clinitest®), but not with glucose enzymatic urine sugar tests (Clinistix®). If you have any questions about this, check with your health care professional.
For patients taking probenecid for gout or to help remove uric acid from the body:
- Taking aspirin or other salicylates may lessen the effects of probenecid. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Also, drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of this medicine. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while taking this medicine, unless you have first checked with your doctor.
For the Consumer
Applies to probenecid: oral tablet
Along with its needed effects, probenecid (the active ingredient contained in Benemid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking probenecid:Rare
- Fast or irregular breathing
- puffiness or swellings of the eyelids or around the eyes
- shortness of breath, troubled breathing, tightness in chest, or wheezing
- changes in the skin color of the face occurring together with any of the other side effects listed here
- or skin rash, hives, or itching occurring together with any of the other side effects listed here
Check with your doctor as soon as possible if any of the following side effects occur while taking probenecid:Less common
- Bloody urine
- difficult or painful urination
- lower back or side pain (especially if severe or sharp)
- skin rash, hives, or itching (occurring without other signs of an allergic reaction)
- Cloudy urine
- cough or hoarseness
- fast or irregular breathing
- pain in back and/or ribs
- sores, ulcers, or white spots on lips or in mouth
- sore throat and fever with or without chills
- sudden decrease in the amount of urine
- swelling of face, fingers, feet, and/or lower legs
- swollen and/or painful glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
- weight gain
Some side effects of probenecid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- joint pain, redness, or swelling
- loss of appetite
- nausea or vomiting (mild)
- flushing or redness of face (occurring without any signs of an allergic reaction)
- frequent urge to urinate
- sore gums
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