Albuterol and ipratropium inhalation

Name: Albuterol and ipratropium inhalation

What is albuterol and ipratropium inhalation?

Albuterol and ipratropium is a combination bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.

Albuterol and ipratropium inhalation is used to prevent bronchospasm in people with chronic obstructive pulmonary disease (COPD) who are also using other medicines to control their condition.

Albuterol and ipratropium inhalation may also be used for purposes not listed in this medication guide.

Precautions

Albuterol-ipratropium is contraindicated in patients with history of hypersensitivity to atropine or its derivatives. Combivent(R) inhalation aerosol is also contraindicated in patients with history of hypersensitivity to soya lecithin or related food products such as soybean and peanut.

Inhaled albuterol-ipratropium can produce paroxysmal bronchoconstriction that can be life-threatening. If this occurs, albuterol-ipratropium therapy should be stopped at once and alternative therapy should be instituted.

Albuterol can produce a clinically significant cardiovascular effect in some patients, as measured by pulse rate, blood pressure, and/or symptoms. If such symptoms occur, albuterol-ipratropium may need to be discontinued. Electrocardiogram changes, such as flattening of T wave, prolongation of QTc interval, and ST segment depression have been reported with beta-adrenergic agents. Albuterol-ipratropium should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension.

Albuterol-ipratropium should be used with caution in patients with narrow-angle glaucoma, prostatic hyperplasia, bladder neck obstruction, convulsive disorders, hyperthyroidism, or diabetes mellitus, and in patients who are unusually responsive to sympathomimetic amines.

Patients should avoid getting albuterol-ipratropium into the eyes as this may result in precipitation or worsening of narrow-angle glaucoma, increased intraocular pressure, acute eye pain or discomfort, temporary blurring of vision, mydriasis, visual halos, or colored images in association with red eyes from conjunctival or corneal congestion. Patients should be advised to contact their physician at once if any such symptoms develop while using albuterol-ipratropium.

Hypersensitivity reactions may occur after administration of ipratropium bromide or albuterol sulfate. If such a reaction occurs, albuterol-ipratropium therapy should be stopped at once and alternative treatment should be considered.

Safety and effectiveness of additional doses of Combivent(R) inhalation aerosol beyond 12 inhalations/24 hours or of Combivent(R) Respimat(R) inhalation spray beyond 6 inhalations/24 hours have not been established. Safety and effectiveness of additional doses of DuoNeb(R) inhalation solution beyond 6 vials (18 mL)/24 hours have not been established.

Safety and effectiveness of extra doses of albuterol or ipratropium in addition to the recommended doses of albuterol-ipratropium have not been established.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

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