Name: Aflibercept (Ophthalmic)
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Aflibercept ophthalmic Dosage
Aflibercept ophthalmic is given as an injection into your eye. Your doctor will use a medicine to numb your eye before giving you the injection. You will receive this injection in your doctor's office or other clinic setting.
For a short time after your injection, your eyes will be checked periodically to make sure the injection has not caused any side effects.
Aflibercept is usually given once every 4 weeks for the first 3 months, and then once every 8 weeks. Follow your doctor's dosing instructions very carefully.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Call your doctor for instructions if you miss an appointment for your aflibercept injection.
What are some things I need to know or do while I take Aflibercept?
- Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
- Use care when driving or doing other tasks that call for clear eyesight.
- Have your eye pressure checked. Talk with your doctor.
- This medicine may raise the chance of very bad and sometimes deadly health problems caused by blood clots, like heart attack and stroke. Talk with the doctor.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust before care begins, during care, and for 3 months after care ends.
- If you get pregnant while taking aflibercept or within 3 months after your last dose, call your doctor right away.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Chest pain or pressure.
- Jaw pain.
- Swelling, warmth, or pain in the leg or arm.
- Change in eyesight, eye pain, or very bad eye irritation.
- Eye redness.
- Eyelid swelling.
- If bright lights bother your eyes.
What are some other side effects of Aflibercept?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Seeing floaters.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Brand Names U.S.
Dosing Renal Impairment
No dosage adjustment necessary.
Dosing Hepatic Impairment
There are no dosage adjustments provided in the manufacturer's labeling (has not been studied); however, no adjustment expected due to minimal systemic absorption.
Concerns related to adverse effects:
• Endophthalmitis/retinal detachment: Intravitreous injections are associated with endophthalmitis, retinal detachments, retinal tear, retinal pigment epithelium tear, and cataract, including traumatic cataract. Use proper aseptic injection techniques. Instruct patients to report any signs of infection (eg, eye pain or redness, photophobia, blurred vision) immediately; manage appropriately.
• Hypersensitivity reactions: Hypersensitivity may present as rash, pruritus, urticaria, severe anaphylactic/anaphylactoid reactions, or severe intraocular inflammation.
• Increased intraocular pressure: Following intravitreal injection, intraocular pressure may increase (acute). Onset is seen within 60 minutes. Sustained increases in intraocular pressure have also been reported (with repeated dosing of intravitreal VEGF inhibitors). Monitor intraocular pressure and optic nerve head perfusion.
• Thromboembolic events: Risk of thromboembolic events (eg, nonfatal stroke/MI, vascular death) may be increased following intravitreal administration of VEGF inhibitors, including aflibercept.
• Women: Women of reproductive potential should use effective contraception prior to initial dose, during treatment, and for at least 3 months after the last dose.
What is the most important information I should know about aflibercept ophthalmic?
You should not use aflibercept if you have swelling inside your eyes, or any type of infection in or around your eyes.
Call your doctor at once if you have eye pain or redness, swelling or puffiness around your eyes, or sudden vision problems at any time during treatment.
Aflibercept ophthalmic side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your eyes, face, lips, tongue, or throat.
Call your doctor at once if you have:
eye pain or redness, swelling around your eyes;
sudden vision problems;
seeing flashes of light or "floaters" in your vision, seeing halos around lights;
increased sensitivity of your eyes to light;
sudden numbness or weakness, especially on one side of the body; or
sudden severe headache, confusion, problems with speech or balance.
Common side effects may include:
red or watery eyes;
swelling of the eyelids; or
mild eye pain or discomfort after the injection.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.