Advate recombinant

Name: Advate recombinant

What is the most important information I should know about recombinant antihemophilic factor?

You should not use this medicine if you have ever had a severe allergic reaction to antihemophilic factor in the past.

Your body may develop antibodies to antihemophilic factor, making it less effective. Call your doctor if this medicine seems to be less effective in controlling your bleeding.

Carefully follow all instructions about how to store this medicine. Each brand of recombinant antihemophilic factor may have specific instructions about keeping the medicine in a refrigerator or at room temperature, and for only a certain number of months.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using recombinant antihemophilic factor?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Important information

You should not use Advate if you have ever had a severe allergic reaction to antihemophilic factor in the past.

Your body may develop antibodies to antihemophilic factor, making it less effective. Call your doctor if this medicine seems to be less effective in controlling your bleeding.

Carefully follow all instructions about how to store this medicine. Each brand of recombinant antihemophilic factor may have specific instructions about keeping the medicine in a refrigerator or at room temperature, and for only a certain number of months.

Before using Advate, your specific blood clotting disorder must be diagnosed as factor VIII deficiency. Human antihemophilic factor will not treat von Willebrand disease.

To be sure Advate is helping your condition and is not causing harmful effects, your blood may need to be tested often. Visit your doctor regularly.

Wear a medical alert tag or carry an ID card stating that you have hemophilia. Any doctor, dentist, or emergency medical care provider who treats you should know that you have a bleeding or blood-clotting disorder.

How should I use Advate?

Use Advate exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Always check the strength of the medicine on the label to be sure you are using the correct potency.

Advate is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Advate is usually given every 8 to 24 hours for 1 to 4 days, depending on the reason you are using the medicine.

This medicine comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Always wash your hands before preparing and giving your injection.

Advate must be mixed with a liquid (diluent) before injecting it. If you store your medicine in the refrigerator, take a medicine and diluent vial out of the refrigerator and allow each to reach room temperature before mixing them.

Gently swirl the medicine and diluent to mix them and allow the medicine to completely dissolve. Do not shake the vial.

After mixing the Advate powder and diluent, keep the mixture at room temperature and use it within 3 hours. Do not put mixed medicine into a refrigerator.

Prepare your dose in a syringe only when you are ready to give yourself an injection. A single-use vial is for one use only. After measuring your dose, throw this vial away, even if there is medicine left in it.

Do not use Advate if it has changed colors or has particles in it. Call your pharmacist for new medication.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

While using Advate, you may need frequent blood tests.

Your body may develop antibodies to antihemophilic factor, making it less effective. Call your doctor if this medicine seems to be less effective in controlling your bleeding.

Carefully follow all instructions about how to store this medicine. Each brand of recombinant antihemophilic factor may have specific storage instructions.

Store the medicine and the diluent in their original container in the refrigerator. Do not freeze.

Before preparing your dose, take the medicine and diluent out of the refrigerator and allow them to reach room temperature.

You may also store the medicine and diluent at room temperature for a period of up to 6 months not to exceed the expiration date. Follow the storage directions on the medicine label.

If you store this medicine at room temperature, do not return it to the refrigerator.

Do not store Advate in bright light. Throw away any leftover medicine and diluent if the expiration date has passed.

Wear a medical alert tag or carry an ID card stating that you have hemophilia. Any doctor, dentist, or emergency medical care provider who treats you should know that you have a bleeding or blood-clotting disorder.

Advate side effects

Get emergency medical help if you have any signs of an allergic reaction to Advate: hives; difficult breathing; feeling light-headed, fainting; swelling of your face, lips, tongue, or throat.

Stop using Advate and call your doctor at once if you have:

  • chest pain;

  • easy bruising, increased bleeding episodes; or

  • bleeding from a wound or where the medicine was injected.

Common Advate side effects may include:

  • nausea, vomiting, diarrhea;

  • headache, dizziness;

  • joint pain;

  • rash;

  • sore throat, cough, stuffy nose;

  • weakness, feeling tired;

  • fever; or

  • pain, swelling, itching, or irritation where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Advate?

Other drugs may interact with Advate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Antihemophilic factor Pregnancy Warnings

Antihemophilic factor has been assign to pregnancy category C by the FDA. Animal reproduction studies have not been reported. There are no controlled data in human pregnancy. Antihemophilic factor is only recommended for use during pregnancy when benefit outweighs risk.

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