Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine

Name: Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Acetaminophen, dextromethorphan, guaifenesin, and phenylephrine dosing information

Usual Adult Dose for Cold Symptoms:

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg oral tablet, or
Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-100 mg-5 mg oral tablet:
2 tablets orally every 4 hours not to exceed 12 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 500 mg-20 mg-400 mg-10 mg oral tablet:
1 tablet orally every 4 to 6 hours not to exceed 6 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg/15 mL oral liquid:
30 mL orally every 4 hours not to exceed 180 mL daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 650 mg-20 mg-400 mg-10 mg/20 mL oral liquid:
20 mL orally every 4 hours not to exceed 6 doses (120 mL) daily

Usual Adult Dose for Influenza:

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg oral tablet, or
Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-100 mg-5 mg oral tablet:
2 tablets orally every 4 hours not to exceed 12 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 500 mg-20 mg-400 mg-10 mg oral tablet:
1 tablet orally every 4 to 6 hours not to exceed 6 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg/15 mL oral liquid:
30 mL orally every 4 hours not to exceed 180 mL daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 650 mg-20 mg-400 mg-10 mg/20 mL oral liquid:
20 mL orally every 4 hours not to exceed 6 doses (120 mL) daily

Usual Pediatric Dose for Cold Symptoms:

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg oral tablet, or
Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-100 mg-5 mg oral tablet:
12 years or older: 2 tablets orally every 4 hours not to exceed 12 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 500 mg-20 mg-400 mg-10 mg oral tablet:
6 to 11 years: 1/2 tablet orally every 4 to 6 hours not to exceed 3 tablets daily.
12 years or older: 1 tablet orally every 4 to 6 hours not to exceed 6 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg/10 mL oral liquid:
6 to 11 years: 10 mL orally every 4 hours not to exceed 50 mL daily.
Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg/15 mL oral liquid:
12 years or older: 30 mL orally every 4 hours not to exceed 180 mL daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 650 mg-20 mg-400 mg-10 mg/20 mL oral liquid:
12 years or older: 20 mL orally every 4 hours not to exceed 6 doses (120 mL) daily

Usual Pediatric Dose for Influenza:

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg oral tablet, or
Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-100 mg-5 mg oral tablet:
12 years or older: 2 tablets orally every 4 hours not to exceed 12 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 500 mg-20 mg-400 mg-10 mg oral tablet:
6 to 11 years: 1/2 tablet orally every 4 to 6 hours not to exceed 3 tablets daily.
12 years or older: 1 tablet orally every 4 to 6 hours not to exceed 6 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg/10 mL oral liquid:
6 to 11 years: 10 mL orally every 4 hours not to exceed 50 mL daily.
Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg/15 mL oral liquid:
12 years or older: 30 mL orally every 4 hours not to exceed 180 mL daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 650 mg-20 mg-400 mg-10 mg/20 mL oral liquid:
12 years or older: 20 mL orally every 4 hours not to exceed 6 doses (120 mL) daily

What other drugs will affect this medicine?

Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking acetaminophen, dextromethorphan, and phenylephrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

For the Consumer

Applies to acetaminophen / dextromethorphan / guaifenesin / phenylephrine: oral capsule, oral liquid, oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Not able to pass urine or change in how much urine is passed.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Usual Adult Dose for Influenza

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg oral tablet, or
Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-100 mg-5 mg oral tablet:
2 tablets orally every 4 hours not to exceed 12 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 500 mg-20 mg-400 mg-10 mg oral tablet:
1 tablet orally every 4 to 6 hours not to exceed 6 tablets daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 325 mg-10 mg-200 mg-5 mg/15 mL oral liquid:
30 mL orally every 4 hours not to exceed 180 mL daily.

Acetaminophen/dextromethorphan/guaifenesin/PE 650 mg-20 mg-400 mg-10 mg/20 mL oral liquid:
20 mL orally every 4 hours not to exceed 6 doses (120 mL) daily

Renal Dose Adjustments

Data not available

Dialysis

Data not available

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