Name: Aceon

Perindopril Interactions

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Perindopril Warnings section above, and any of the following:

  • Gengraf, Neoral, or Sandimmune (cyclosporine)
  • Diuretics (water pills)
  • Heparin
  • Lithobid (lithium)
  • Nonsteroidal anti-inflammatory drugs (NSAIDS), such as Advil or Motrin (ibuprofen) and Indocin (indomethacin)
  • Insulin and other diabetes medicines
  • Gold injections for arthritis
  • Nonprescription medicines that contain stimulants (may include diet pills and cold medicines)

Perindopril and Other Interactions

Perindopril may cause dizziness, lightheadedness, or fainting.

Use caution when driving, operating machinery, or performing other tasks that require alertness.

Perindopril and Alcohol

Alcohol may increase the risk of certain side effects of perindopril.

Don't drink alcoholic beverages while taking this drug without first talking to your doctor.

Perindopril Dosage

Perindopril comes as a tablet to take by mouth, usually once or twice daily.

Your dose will depend on your medical condition, response to treatment, and other factors.

Your doctor may start you on a low dose of perindopril and gradually increase it.

Follow the instructions on your prescription label carefully. Don't take more or less perindopril than is recommended.

Try to take this medicine around the same time each day.

Keep taking perindopril even if you feel well. Don't stop using this medicine without first talking with your doctor.

Perindopril Overdose

Symptoms of a perindopril overdose may include:

  • Severe dizziness or lightheadedness
  • Fainting
  • Weakness

If you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

Missed Dose of Perindopril

If you miss a dose of perindopril, take it as soon as you remember.

But if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular medication schedule.

Don't double up on doses to make up for a missed one.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling extremely dizzy or light-headed, or fainting.


Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Perindopril Arginine Combinations


Dosage Forms


Brand Names




3.5 mg with Amlodipine Besylate 2.5 mg (of amlodipine)



7 mg with Amlodipine Besylate 5 mg (of amlodipine)



14 mg with Amlodipine Besylate 10 mg (of amlodipine)



* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Perindopril Erbumine


Dosage Forms


Brand Names




2 mg*

Aceon (scored)


Perindopril Erbumine Tablets

4 mg*

Aceon (scored)


Perindopril Erbumine Tablets

8 mg*

Aceon (scored)


Perindopril Erbumine Tablets

Precautions While Using Aceon

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.

Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of intestinal angioedema.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up from a lying or sitting position or if you have been taking a diuretic (water pill). Make sure you know how you react to the medicine before you drive, use machines, or do other things that could be dangerous if you are dizzy or not alert. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Check with your doctor immediately if you have a fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cells.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Do not use salt substitutes containing potassium without first checking with your doctor.

Check with your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. C

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery.

Do not take other medicines unless they have been discussed with your doctor. This includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

Uses of Aceon

  • It is used to treat high blood pressure.
  • It is used to prevent heart attacks.
  • It may be given to you for other reasons. Talk with the doctor.

Dosage Forms and Strengths

Tablets are oblong with a score on one side.

2 mg tablet is white and debossed on the unscored side with "ACN 2".

4 mg tablet is pink and debossed on the unscored side with "ACN 4".

8 mg tablet is salmon and debossed on the unscored side with "ACN 8".


Aceon® (perindopril erbumine) is contraindicated in patients known to be hypersensitive (including angioedema) to this product or to any other ACE inhibitor. Aceon is also contraindicated in patients with hereditary or idiopathic angioedema.

Do not co-administer aliskiren with Aceon in patients with diabetes. [see Drug Interactions (7.8)]

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenicity:  No evidence of carcinogenic effect was observed in studies in rats and mice when perindopril was administered at dosages up to 20 times (mg/kg) or 2 to 4 times (mg/m2) the maximum proposed clinical doses (16 mg/day) for 104 weeks.

Mutagenesis:  No genotoxic potential was detected for Aceon, perindoprilat and other metabolites in various in vitro and in vivo investigations, including the Ames test, the Saccharomyces cerevisiae D4 test, cultured human lymphocytes, TK ± mouse lymphoma assay, mouse and rat micronucleus tests and Chinese hamster bone marrow assay.

Impairment of Fertility:  There was no meaningful effect on reproductive performance or fertility in the rat given up to 30 times (mg/kg) or 6 times (mg/m2) the proposed maximum clinical dosage of Aceon during the period of spermatogenesis in males or oogenesis and gestation in females.

Aceon Overview

Aceon is a prescription medication used to treat high blood pressure. It is also used to reduce the risk of death or heart attack in people with coronary artery disease. Aceon belongs to a group of drugs called angiotensin converting enzyme (ACE) inhibitors, which relax blood vessels to lower blood pressure and make the heart more efficient.

This medication comes in tablet form and is taken once or twice daily, with or without food. It should be taken at the same time(s) each day.

Common side effects of Aceon include cough, headache, and back pain. Aceon may also cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.

Aceon and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known whether Aceon crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Aceon.


Aceon Usage

  • Take Aceon exactly as prescribed.
  • Aceon comes in tablet form and is usually taken once or twice daily.
  • It can be taken with or without food.
  • This medication should be taken at around the same time each day.
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Aceon at the same time.

What should I avoid while taking Aceon?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use salt substitutes or potassium supplements while taking Aceon, unless your doctor has told you to.

Perindopril Breastfeeding Warnings

AU and UK: Use is not recommended. US: Caution is recommended. Excreted into human milk: Unknown Excreted into animal milk: Yes Comments: The effects in the nursing infant are unknown.