Abiraterone Acetate

Name: Abiraterone Acetate

What are some things I need to know or do while I take Abiraterone Acetate?

  • Tell all of your health care providers that you take abiraterone acetate. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • High blood pressure has happened with this medicine. Have your blood pressure checked as you have been told by your doctor.
  • Do not let women who are pregnant or of childbearing age touch the tablets without wearing gloves.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy. Use a condom and another form of birth control that you can trust during care and for 1 week after care ends.
  • If you are a man and your sex partner gets pregnant while you take abiraterone acetate or within 1 week after your last dose, call your doctor right away.
  • If you are having sex and your partner is pregnant, use a condom during care and for 1 week after care ends.

How is this medicine (Abiraterone Acetate) best taken?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with prednisone as you have been told by your doctor.
  • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
  • Take with a full glass of water.
  • Swallow tablet whole. Do not chew, break, or crush.
  • To gain the most benefit, do not miss doses.
  • Keep taking abiraterone acetate as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • If you miss a dose, wait until the next day to take your normal dose.
  • Do not take 2 doses at the same time or extra doses.
  • If you miss 2 doses, call your doctor.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about abiraterone acetate, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about abiraterone acetate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using abiraterone acetate.

Review Date: October 4, 2017

Use Labeled Indications

Prostate cancer: Treatment of metastatic, castration-resistant prostate cancer (in combination with prednisone)

Dosing Adult

Prostate cancer, metastatic, castration-resistant: Oral: 1,000 mg once daily (in combination with prednisone 5 mg twice daily)

Prostate cancer, metastatic or high-risk locally advanced, castration-sensitive (off-label use): Oral: 1,000 mg once daily (in combination with prednisone 5 mg once daily and androgen-deprivation therapy; Fizazi 2017) or 1,000 mg once daily (in combination with prednisolone 5 mg once daily and androgen-deprivation therapy; James 2017)

Dosage adjustment for concomitant strong CYP3A4 inducers: Avoid concomitant strong CYP3A4 inducers; if a strong CYP3A4 inducer must be administered concurrently, increase the abiraterone frequency to twice daily (eg, from 1,000 mg once daily to 1,000 mg twice daily). Upon discontinuation of the strong CYP3A4 inducer, reduce abiraterone back to the prior dose and frequency.

Dosing Renal Impairment

No dosage adjustment necessary.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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