A-Phedrin

Name: A-Phedrin

What is the most important information I should know about pseudoephedrine and triprolidine?

You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

How should I take pseudoephedrine and triprolidine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What other drugs will affect pseudoephedrine and triprolidine?

Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by triprolidine.

Ask a doctor or pharmacist if it is safe for you to take pseudoephedrine and triprolidine if you are also using any of the following drugs:

  • atropine (Atreza, Sal-Tropine);

  • benztropine (Cogentin);

  • topiramate (Topamax);

  • zonisamide (Zonegran);

  • anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;

  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

  • irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

  • ulcer medicine such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

This list is not complete and other drugs may interact with pseudoephedrine and triprolidine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

For the Consumer

Applies to pseudoephedrine / triprolidine: oral liquid, oral tablet

Usual Adult Dose for Cold Symptoms

Tablets:
Pseudoephedrine-triprolidine 60 mg-2.5 mg
1 tablet orally every 4-6 hours; do not exceed 4 doses in 24 hours.

Syrup:
Pseudoephedrine-triprolidine 30 mg-1.25 mg/mL oral liquid
10 mL orally every 4-6 hours; do not exceed 4 doses in 24 hours.

Liquid:
Pseudoephedrine-triprolidine 10 mg-0.938 mg/mL oral liquid:
2.67 mL orally every 6 hours. Do not take more than 4 doses in 24 hours.
Pseudoephedrine-triprolidine 45 mg-2.5 mg/5 mL oral liquid:
5 to 10 mL orally every 4 to 6 hours. (maximum pseudoephedrine: 240 mg/24 hours).

Usual Pediatric Dose for Allergic Rhinitis

Tablets:
Pseudoephedrine-triprolidine 60 mg - 2.5 mg.
6 years to 12 years: 1/2 tablet orally every 4-6 hours; do not exceed 4 doses in 24 hours.
13 years or older: 1 tablet orally every 4-6 hours; do not exceed 4 doses in 24 hours.

Syrup:
Pseudoephedrine-triprolidine 30 mg - 1.25 mg.
6 years to 12 years: 5 mL orally every 4-6 hours; do not exceed 4 doses in 24 hours.
13 years or older: 10 mL orally every 4-6 hours; do not exceed 4 doses in 24 hours.

Liquid:
Pseudoephedrine-triprolidine 10 mg-0.938 mg/mL oral liquid:
6 years to 11 years: 1.33 mL orally every 6 hours. Do not take more than 4 doses in 24 hours.
12 years or older: 2.67 mL orally every 6 hours. Do not take more than 4 doses in 24 hours.
Pseudoephedrine-triprolidine 45 mg-2.5 mg/5 mL oral liquid:
6 years to 11 years: 2.5 to 5 mL orally every 4 to 6 hours. (maximum pseudoephedrine: 120 mg/24 hours).
12 years or older: 5 to 10 mL orally every 4 to 6 hours. (maximum pseudoephedrine: 240 mg/24 hours).

Dialysis

Data not available

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